Products
Phenazone
Phenazone (historically known as Antipyrine) is a classical pyrazolone derivative showcasing reliable analgesic and antipyretic activities. It acts centrally to raise the pain threshold and modify thermoregulation. Primarily used today in combination ear drops to provide rapid, soothing topical analgesia for acute otitis media, it helps safely alleviate intense localized ear pain.
Get Pharmaceutical Grade Phenazone API in India
Product Specifications
| Phenazone API Technical Details | |
|---|---|
| Product Name | Phenazone (Antipyrine) |
| Category | Active Pharmaceutical Ingredient (API) |
| Chemical Name | 1,5-Dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one |
| Synonyms | Antipyrine, Phenazon, Analgesine, Anodynine |
| CAS Number | 60‑80‑0 |
| EC Number | 200‑486‑6 |
| UNII | T3CHA1B51H |
| Molecular Formula | C₁₁H₁₂N₂O |
| Molecular Weight | 188.23 g/mol |
| Appearance | White or almost white crystalline powder |
| Purity | ≥ 99.0% (dried substance) |
| Melting Point | 110–113°C (crystals); 174–177°C (reported range) |
| Solubility | Very soluble in water, ethanol (96%), and methylene chloride |
| Pharmacopoeia Compliance | European Pharmacopoeia (EP), BP, In‑house |
| Therapeutic Class | Analgesic, Antipyretic, Anti-inflammatory (NSAID) |
| Application | Ear drops, oral analgesic formulations, diagnostic reagent |
| Form | Crystalline Powder |
| Packaging | HDPE container / Aluminum foil bag |
| Shelf Life | 3 years |
| Storage Conditions | Store below 30°C, protect from light and moisture |
| Certifications / Compliance | GMP, In‑house QC tested, CoA available |
| Hazard Classification | Acute toxicity (oral), Category 4 (H302) |
Phenazone (INN/BAN), also known as Antipyrine, is a well-established non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-inflammatory properties. As one of the oldest synthetic drugs, it continues to serve as a trusted active pharmaceutical ingredient in modern medicine—particularly in otic (ear drop) formulations for pain relief and wax softening.
As a premier API manufacturer and supplier in India, SNA Healthcare delivers pharmaceutical-grade Phenazone that meets European Pharmacopoeia (EP) and in-house quality standards. Our Phenazone API is characterized by high purity (≥99%), consistent crystalline structure, and verified solubility profiles—making it an ideal starting material for analgesic, antipyretic, and diagnostic reagent formulations.
Phenazone API Applications in Pharmaceutical Manufacturing
Analgesic and Antipyretic Formulations
Phenazone is widely used in oral and topical formulations for relief of mild to moderate pain (headache, muscle pain, back pain) and fever reduction. Its mechanism involves inhibition of COX enzymes (COX-1, COX-2, COX-3), reducing prostaglandin synthesis.
Otic (Ear Drop) Preparations
Phenazone 5% w/v ear drops are commonly prescribed for otalgia (ear pain) and ear wax softening. Its high water solubility and anti-inflammatory action make it ideal for local application in the ear canal.
Diagnostic and Biochemical Reagent
Phenazone (Antipyrine) is used as a marker compound to assess hepatic enzyme drug-metabolizing activity in clinical and research settings. Its pharmacokinetic profile helps evaluate liver function and drug interaction studies.
Pharmaceutical Intermediate
Beyond direct API use, Phenazone serves as a chemical intermediate in the synthesis of pyrazolone derivatives and specialty compounds for the pharmaceutical and chemical industries.
Quality Assurance for Multi-Step Synthesis
In complex pharmaceutical synthesis, the quality of the starting material determines final product reliability. Our Phenazone API undergoes rigorous in-house QC testing, with CoA documentation, ensuring batch-to-batch consistency for critical manufacturing processes.
Source Trusted Phenazone API from India!
Phenazone remains a cornerstone API for analgesic,
