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Efonidipine Hcl Ethanolate
Efonidipine hydrochloride ethanolate is a prescription calcium-channel blocker used mainly to lower high blood pressure and, in some settings, to treat angina (heart-related chest pain). It is a dihydropyridine drug that blocks both L-type and T-type calcium channels, relaxing blood vessels and reducing cardiac workload
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Product Specifications
| Efonidipine HCl Ethanolate API Technical Details | |
|---|---|
| Product Name | Efonidipine HCl Ethanolate (Efonidipine Hydrochloride Ethanolate) |
| Category | API – Organic / Cardiovascular |
| Chemical Name | 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2λ⁵-dioxaphosphinan-2-yl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate hydrochloride ethanolate |
| CAS Number | 111011-76-8 |
| Molecular Formula | C₃₆H₄₅ClN₃O₈P |
| Molecular Weight | 714.19 |
| Pharmacopoeia Compliance | IP / BP / USP / EP / JP / In-house |
| Therapeutic Category / Application | Antihypertensive; calcium channel blocker (L- and T-type); management of essential hypertension and related cardiovascular indications |
| Form | Powder / tablet-grade API |
| Packaging | Blister packs, bottles, HDPE drums (as per customer requirement) |
| Shelf Life | 2–4 years |
| Storage Conditions | Cool, dry, sealed; protect from light and moisture |
| Certifications / Compliance | GMP-compliant facility; prescription-only API; regulatory documentation available (COA, MOA, stability data) |
Efonidipine HCl Ethanolate is a dihydropyridine calcium channel blocker with dual L- and T-type channel inhibition, used primarily in the management of essential hypertension and related cardiovascular conditions. As an API, it serves as the key active pharmaceutical ingredient for manufacturers producing oral antihypertensive tablets and formulations.
As a responsible API Manufacturer in India, SNA Healthcare supplies high-purity Efonidipine HCl Ethanolate to pharmaceutical companies engaged in cardiovascular therapeutics. Our role as an Efonidipine supplier is to ensure that manufacturers receive consistent, high-quality API that meets stringent pharmacopoeial and regulatory expectations.
Efonidipine HCl Ethanolate API Profile for Antihypertensive Formulations
Dual L- and T-Type Calcium Channel Blockade
Efonidipine blocks both L-type and T-type calcium channels, resulting in vasodilation of peripheral and coronary arteries along with favorable effects on heart rate and blood pressure control. This dual mechanism supports effective management of mild-to-moderate hypertension.
Blood Pressure and Heart Rate Control
Clinical evidence indicates that efonidipine can significantly reduce both blood pressure and heart rate in hypertensive patients, making it suitable for patients where heart rate modulation is desirable alongside BP lowering.
Predictable Potency and Purity
For a cardiovascular API with precise dosing requirements, exceptional chemical purity and consistent physical properties are critical. Our Efonidipine HCl Ethanolate is manufactured to ensure uniform potency, supporting accurate tablet dosing and reproducible therapeutic effect.
Optimized for Oral Dosage Forms
Efonidipine is typically formulated as oral tablets (e.g., 10 mg, 20 mg, 40 mg strengths). The API's particle characteristics and stability profile are optimized to enable robust tablet manufacturing with uniform content and reliable dissolution.
Inquire for APIs!
Efonidipine HCl Ethanolate is a critical API in cardiovascular medicine, offering dual L- and T-type calcium channel blockade for effective antihypertensive therapy. The dependability, purity, and regulatory compliance of the API are essential for producing safe, efficacious finished dosage forms. SNA Healthcare can provide you with an ingredient which meets these exact standards. Contact us to learn more about our high-quality Efonidipine HCl Ethanolate API supply and partnership opportunities.
